Grupo-D
Dinamo Zagreb 0 x 1 PAOK Thessaloniki
G: Salpigidis
Brugge 1 x 2 Villarreal
G: Kouemaha; Rossi (2)
Grupo-E
Dinamo Kyiv 0 x 0 Sheriff Tiraspol
AZ Alkmaar 3 x 0 Bate Borisov
G: Sigpórsson (2) e Maher
Grupo-F
Sparta Praha 1 x 1 CSKA Moscow
G: Kadlec; Dzagoev
Lausanne-Sport 0 x 1 Palermo
G: Muñoz
Grupo-J
Sevilla 2 x 2 Borussia Dortmund
G: Romaric e Kanouté; Kagawa e Subotic
Karpaty Lviv 1 x 1 Paris Saint-Germain
G: Fedetskiy; Luyindula
Grupo-K
Liverpool 0 x 0 Utrecht
Napoli 1 x 0 Steaua Bucuresti
G: Cavani
Grupo-L
Porto 3 x 1 CSKA Sofia
G: Otamendi, Micael e Rodríguez; Delev
Besiktas 2 x 0 Rapid Wien
G: Quaresma e Ernst
Quinta-Feira - 16/12/2010
Grupo-A
Juventus 1 x 1 Manchester City
G: Giannetti; Jô
Salzburg 0 x 1 Lech Poznan
G: Stilic
Grupo-B
Bayer Leverkusen 1 x 1 Atlético Madrid
G: Helmes; Mérida
Aris Thessaloniki 2 x 0 Rosenborg
G: Cesarec e Faty
Grupo-C
Lille 3 x 0 Gent
G: Obraniak, Frau e Sow
Levski Sofia 1 x 0 Sporting Lisboa
G: Mladenov
Grupo-G
Anderlecht 2 x 0 Hajduk Split
G: De Sutter e Suárez
AEK Athens 0 x 3 Zenit
G: Bukharov, Rosina e Denisov
Grupo-H
Getafe 1 x 0 Young Boys
G: Sardinero
Stuttgart 5 x 1 Odense
G: Gebhart, Hoegh, Gentner, Pogrebnyak e Marica; Utaka
Grupo-I
PSV Eindhoven 0 x 0 Metalist Kharkiv
Debrecen 2 x 0 Sampdoria
G: Kabát (2)
Classificados para a 2ª fase:
Manchester City, Lech Poznán, Bayer Leverkusen, Aris, Sporting Lisboa, Lille, Villarreal, PAOK, Dynamo Kyiv, BATE Borisov, CSKA Moscow, Sparta Praha, Zenit, Anderlecht, Stuttgart, Young Boys, PSV Eindhoven, Metalist Kharkiv, Paris Saint-Germain, Sevilla, Liverpool, Napoli, Porto, Besiktas, Rangers, Ajax, Braga, Spartak Moscow, Basel, Rubin Kazan, Benfica e Twente.
Eliminados:
Rapid Wien, CSKA Sofia, Steaua Bucuresti, Utrecht, Borussia Dortmund, Karpaty Lviv, Sampdoria, Debrecen, Getafe, Odense, AEK Athens, Hajduk Split, Palermo, Lausanne-Sport, AZ Alkmaar, Sheriff Tiraspol, Dinamo Zagreb, Brugge, Gent, Levski Sofia, Atlético Madrid, Rosenborg, Juventus e Red Bull Salzburg.